CAPMATINIB IS AN EFFECTIVE TREATMENT FOR MET-FUSION DRIVEN PEDIATRIC HIGH-GRADE GLIOMA AND SYNERGIZES WITH RADIOTHERAPY

Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy

Abstract Background Pediatric-type diffuse high-grade glioma (pHGG) is the most frequent malignant brain tumor in children and can be subclassified into multiple entities.Fusion genes activating the MET receptor tyrosine kinase often occur in infant-type hemispheric glioma (IHG) but also in other pHGG and are associated with devastating morbidity a

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Fabrication and Characterization of Chitosan/Poly(Lactic-Co-glycolic Acid) Core-Shell Nanoparticles by Coaxial Electrospray Technology for Dual Delivery of Natamycin and Clotrimazole

Natamycin (NAT) is the drug of choice for the treatment of fungal keratitis (FK).However, its inherent shortcomings, such as poor solubility, high dosing frequency, and long treatment cycle, need to be urgently addressed by designing a new delivery to widen its clinical utility.Growing research has confirmed that clotrimazole (CLZ) plays a signific

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